Insulin lispro is physically compatible with eli lillys intermediateacting human insulins humulin n, humulin l and longeracting human insulin humulin u. Lists the various brand names available for medicines containing insulin lispro. Oct 07, 2019 insulin is a hormone that works by lowering levels of glucose sugar in the blood. This way you can give yourself one injection or shot instead of two. Insulin lispro is a shortacting, manmade version of human insulin. Jun 19, 2017 insulin needs may be altered during stress, major illness, or changes in exercise, meal patterns, or coadministered drugs. Find information on insulin lispro, rdna origin admelog, humalog in daviss drug guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more.
Generic name insulin lispro pronounced in soo lin lye spro no generic available common brand names humalog, humalog kwikpen, humapen, other humalog pens type of insulin, onset, duration rapidacting insulin. Feb 12, 2020 never share an insulin lispro injection prefilled pen or syringe between patients, even if the needle is changed. This leads to lispros more rapid absorption and shorter duration of action compared with regular insulin when given by subcutaneous injection. This medicine is a rapidacting insulin that starts working faster than regular insulin. Therefore, the objective of the present study was to examine whether insulin lispro. Insulin lispro humalog, the first marketed insulin. Patients using vials must never share needles or syringes with another person. It is used by injection under the skin or within an insulin.
Areas of fatty tissue are shaded in the image below. Comparison of insulin aspart and lispro diabetes care. Never share a humalog, insulin lispro injection, humalog mix7525, or humalog mix5050 prefilled pen, cartridge, reusable pen compatible with lilly 3 ml cartridges, or syringe between patients, even if the needle is changed. Dailymed insulin lispro injection, solution insulin. Insulin itself is not considered a reproduction hazard. Once opened, good for 42 days tresiba flextouch u200 pen 200. Diabetes treatment humalog insulin lispro injection. Insulin lispro injection is a rapidacting human insulin analog used to lower blood glucose. If using this site, do not use the area within one inch of your belly button. In an embryofetal development study in pregnant rabbits, insulin lispro doses of 0. Insulin lispro sanofi 100 einheitenml injektionslosung in einem fertigpen. Administer insulin lispro within 15 min before a meal.
Insulin lispro sanofi mein sanofi sanofiaventis deutschland. Prior to withdrawing dose, rotate vial between palms to ensure uniform solution. Atkinson, in williams textbook of endocrinology thirteenth edition, 2016. Do not administer solution that appears thickened, cloudy, discolored or contains particles. Your healthcare provider should tell you if you should pinch the skin before injecting. Do not transfer humalog u200 from the humalogkwikpen to a syringe as overdosage and severe. This drug lowers the amount of sugar in your blood. Pdf management of diabetes mellitus with insulin lispro. Insulin lispro, sold under the brand name humalog among others, is a type of insulin used to treat type 1 and type 2 diabetes. Injection site effects on the pharmacokinetics and. Insulin lispro protamine is an intermediateacting insulin. Instruct patients to check insulin labels before injection. Once opened, good for 28 days toujeo solostar u300 pen 300 units insulin ml glargine lantus basal 3 xs concentration of u100 insulin 1.
However, it is not known whether insulin lispro crosses the human placenta and reaches the fetus. Chronic exposure data for insulin, and insulin, lispro. Never share a humalog, insulin lispro injection, humalog mix7525, or humalog mix5050 prefilled pen, cartridge, reusable pen compatible with lilly 3 ml cartridges, or syringe between patients, even if the. Lillys ultra rapid lispro provided similar a1c reductions. Pdf insulin lispro humalog is a recombinant human insulin analogue with reversed amino acids at position 28 and 29 on the insulin bchain. Feb 24, 1998 insulin lispro has a much faster, higher and shorterlasting peak serum insulin level than regular human insulin, thus mimicking physiologic secretion of insulin more closely. It may include links to online content that was not created by michigan medicine and for which michigan medicine does not assume. After subcutaneous injection of an equal amount of either insulin lispro or aspart into the same patients, free insulin reached similar concentrations. Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in insulin dose. Implement aerobic exercise and endurance training programs to maintain optimal body weight, improve insulin sensitivity, and reduce the risk of macrovascular disease heart attack, stroke and microvascular problems reduced blood flow to tissues and organs that causes poor wound healing, neuropathy, retinopathy, and nephropathy. Insulin lispro has a much faster, higher and shorterlasting peak serum insulin level than regular human insulin, thus mimicking physiologic secretion of insulin more closely. Patients using insulin lisproinjectionvials must never share needles or syringes with another person. Insulin lispro u100 insulin glulisine u100 literature search summary a literature search was performed on pubmedmedline 1966 to february 27, 2015 using the search term insulin lispro 200.
Insulin lispro injection kwikpenpen is a disposable singlepatientuse prefilled pen containing 300units of insulin lispro. Insulin lispro sanofi, inn insulin lispro european medicines agency. Pdf pharmacokinetics and glucodynamics of insulin lispro. Insulin, lispro crystals rat, 10 unitskg, no deaths or toxicity. Many other medicines can increase or decrease the effects of insulin lispro on lowering blood sugar. Insulin lisproinjectionstarts acting fast,so give your injection within 15 minutes before or right after you eat a meal.
Insulin lispro and insulin lispro protamine uses, side. Different types of insulin work at different speeds in the body. Insulin lispro, of recombinant dna origin, is a human insulin analogue created by reversal of the amino acids at positions 28 and 29 on the human insulin b chain. Contraindications humalog, insulin lispro injection, humalog mix7525, and humalog mix5050 are. The unit markings on the insulin syringe must match the insulins unitsml. Insulin, lispro crystals rhesus monkeys, extremely weak immunogenic potential. Pharmacopeial method for the determination of insulin lispro employed mobile phase constituted by phosphate buffer solution 0. Humalog may interact with albuterol, clonidine, reserpine, guanethidine, or betablockers.
The unit markings on the insulin sy ringe must match the insulin. Find information on insulin lispro use, treatment, drug class and molecular formula. Objective insulin lispro humalog, a human insulin analog, has a more rapid onset, earlier peak, and shorter duration of glucose lowering activity than regular human insulin. Tm 50% insulin lispro protamine suspension, 50% insulin lispro injection rdna origin lilly 1530 minutes 0. Humalog is a rapid acting human insulin analog indicated to improve glycemic control in adults and children with diabetes mellitus. Using the mesh terms, lispro and insulin analogues, we searched pubmed, current contents, medline. Avoid using the belt line area since rubbing may irritate the site. Some insulins, like glargine lantus and detemer levemir, cannot be mixed.
Insulin lispro injection prefilled pensmust never be shared between patients, even if the needle is changed. Rapid lispro results in accelerated insulin lispro absorption. Humalog ist, verglichen mit normalinsulin, bei subkutaner anwendung ein praparat mit rascherem. Insulin lispro is injected under the skin with a syringe and needle, an injection pen, or with an infusion pump. You can givefrom 1 to 60units in a singleinjection. Indianapolis, june 9, 2019 prnewswire two phase 3 studies show that eli lilly and companys nyse. Regular insulin brand name examples humulinr novolinr relion r from walmart. You can give yourself more than1 dose from the pen. Sep 12, 2019 in an embryofetal development study in pregnant rabbits, insulin lispro doses of 0. Humalog kwikpen insulin lispro injection 100 unitsml 3 disclaimer. Drug information table insulin lispro humalog, regular. Kolaczynski, md, phd guenther boden, md objective to compare insulin levels and actions in patients with type 1 diabetes after subcutaneous injection of the rapidacting insulin analogs aspart. It may include links to online content that was not created by michigan medicine and for which michigan medicine.
Lly ultra rapid lispro urli provided noninferior a1c reductions compared to humalog insulin lispro at 26 weeks in people with type 1 and type 2 diabetes. Sharing poses a risk for transmission of bloodborne pathogens. Regular insulin can be injected up to 30 minutes before the start of a meal if patient is taking this. Insulin is a hormone that works by lowering levels of glucose sugar in the blood. Insulin lispro is produced by recombinant dna technology utilizing a nonpathogenic laboratory strain of escherichia coli. As a result, there is improvement in postprandial blood glucose levels and decreased episodes of hypoglycemia, with no change in the hemoglobin a1c hgba1c level. Insulin lispro is a fastacting insulin that starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours insulin lispro is used to improve blood sugar control in adults and children with diabetes mellitus insulin lispro is used to treat type 2 diabetes in. For insulin suspensions cloudy insulins, gently rotate the vial between your palms to disperse the particles. Steps to draw up and inject insulin injection sites insulin injections are given into fatty tissue. Comparison of insulin aspart and lispro pharmacokinetic and metabolic effects carol homko, rn, phd antonio deluzio, do carolyn jimenez, phd jerzy w. Insulin lispro in su lin lye sproe is a humanmade form of insulin. Due to the short duration of action, insulin lispro must be used with a longer act inginsulin,insulininfusionpumporincombinationwithoralsulfonureaagents. Doses between 5 and 20 units of insulin administered intravenously as a bolus or up to a 60minute infusion have. Pdf the modification of the human insulin structure resulting in insulin lispro has been successful in its purpose.
Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in insulin. Insulin aspart, insulin glulisine, or insulin lispro also. Important safety information for humalog brand of insulins and insulin lispro injection. This document contains information andor instructional materials developed by michigan medicine for the typical patient with your condition. Objective the pharmacokinetics and glucodynamics of a new insulin analog, insulin lispro, and regular human insulin were compared and contrasted after subcutaneous administrations in femoral, deltoid, and abdominal injection sites. Mixing two insulins since your doctor has ordered 2 kinds of insulin that can be mixed, you need to learn how to mix the two insulins together in one syringe.
Humalog insulin lispro dose, indications, adverse effects. Insulin lispro, rdna origin admelog, humalog daviss drug. Insulin lispro, rdna origin admelog, humalog daviss. You can give yourself more than 1 dose from the pen. Insulin lispro is equipotent to regular insulin, but with more rapid activity and a shorter duration of action when given via intermittent subcutaneous injection. Insulin lispro was the first insulin analogue to receive approval by the u. Giving your insulin lispro injectionwith a syringe inject your insulin exactly as your healthcare provider has shown you. Dailymed humalog insulin lispro injection, solution. Insulin, regular injection, concentrated daviss drug. Drug information table insulin lispro humalog, regular humulin r, nph humulin n, insulin glargine lantus therapeutic use administration health care professional administration patient diabetes mellitus type 1, type 2, gestational injection considerations give subcutaneously using an insulin syringe or iv humulin r. Do not mix insulin glargine or insulin detemir with any other insulin.
Insulin lispro kwikpen pen is a disposable prefilled pen containing 300units of insulin lispro. Instructions for use insulinlisproinjection kwikpen. Each turn click of the dose knob dials 1 unit of insulin. Insulin lispro humalog, the first marketed insulin analogue. Changes to an insulin regimen should be made cautiously and only under medical supervision. Rapidacting insulin analogues for the treatment of diabetes. When mixing insulins, draw regular insulin into syringe. Kolaczynski, md, phd guenther boden, md objective to compare insulin levels and actions in patients with type 1 diabetes after subcutaneous injection of the rapidacting insulin analogs aspart and lispro. When mixing shortacting insulin with longeracting insulin, draw the shortacting insulin into the syringe first, then the longeracting insulin. Insulin lispro is a fastacting insulin that starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. This chart breaks down the types of insulin, their duration, and the different brands available. Administer insulin lispro injection by subcutaneous injection into the abdominal wall, thigh, upper arm, or buttocks within 15 minutes before a meal or immediately after a meal. Transfer of insulin lispro across the human placenta.
You can give from 1 to 60units in a single injection. Instructions for mixing with other insulins humalog u100subcutaneousinjectionroute humalog u100 maybe mixed with nph insulin preparations only. Insulin lispro sanofi 100 units ml solution for injection in a prefilled pen. Dosage adjustment may be needed when switching from another insulin to humalog see warnings and precautions 5. Development of a new hplc method for the determination of. Side effects of humalog insulin lispro human analog.
Never share an insulin lispro injection prefilled pen or syringe between patients, even if the needle is changed. Humalog kwikpen u200 200 units insulin ml lispro humalog bolus 2 xs concentration of u100 insulin. Insulin lispro humalog is a recombinant human insulin analogue with reversed amino acids at position 28 and 29 on the insulin bchain lysb28, prob29. Humalog insulin lispro injection, for subcutaneous or intravenous use. A healthcare provider will teach you how to properly use this medicine by yourself. Humalog insulin lispro injection, usp rdna origin for injection. The search was limited to studies performed in humans and published in the english language. Hyperglycemia or hypoglycemia with changes in insulin regimen. Humalog kwikpen insulin lispro injection 100 unitsml. Retention time was estimated to be 25 minutes and the temperature of the column maintained to 40. Oct 08, 2019 insulin lispro u100 humalogr may be diluted with insulin diluting medium for humalog to provide concentrations of u10 or u50. Generalized allergy to insulin may present as a whole body rash, dyspnea, wheezing, hypotension, tachycardia, or diaphoresis.
Highlights of prescribing information do not use in. In clinical trials, pruritus with or without rash was seen in 17 patients receiving human insulin n2969 and 30 patients receiving insulin lispro. Insulin lispro works by replacing the insulin that is normally produced by the body and by helping move sugar from the blood into other body tissues where it is used for energy. Dailymed insulin lispro injection, solution insulin lispro. In a combined fertility and embryofetal development study, female rats were given subcutaneous insulin lispro injections of 1, 5, and 20 unitskgday 0. Glucose monitoring is essential for patients receiving insulin therapy.